Cart
sales@molnova.com
Home - Products - Others - Other Targets - PF-06424439 methanesulfonate

PF-06424439 methanesulfonate

CAS No. 1469284-79-4

PF-06424439 methanesulfonate( —— )

Catalog No. M26369 CAS No. 1469284-79-4

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 50 Get Quote
10MG 87 Get Quote
25MG 177 Get Quote
50MG 295 Get Quote
100MG 484 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-06424439 methanesulfonate
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
  • Description
    PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM). PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.(In Vivo):PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male low-density lipoprotein receptor (Ldlr) knockout mice (Ldlr-/-)Dosage:60 mg/kg Administration:P.o.; daily; for 3 days Result:Reduced plasma TG and cholesterol levels and decreased nonsignificant in circulating lipids.Animal Model:Male Wistar-Han ratsDosage:1 mg/kg Administration:I.v.Result:Showed moderate clearance and a short half-life with t1/2=1.39 h.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PI4Kα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1469284-79-4
  • Formula Weight
    536.05
  • Molecular Formula
    C23H30ClN7O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (466.37 mM)
  • SMILES
    CS(O)(=O)=O.Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anna Lindsey Banka, et al. Quinazolinone derivatives as antiviral agents.WO2012087938A1
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ZLDI-8

    ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.ZLDI-8;?it inhibited the cleavage of NOTCH protein, consequently decreased the expression of pro-survival/anti-apoptosis and EMT related proteins.?

  • Monoethyl malonic ac...

    Monoethyl malonic acid belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. Monoethyl malonic acid exists as a solid soluble (in water) and a weakly acidic compound (based on its pKa).

  • LDC-4297 HCl

    LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.

Sign In Join Free