PF-06424439 methanesulfonate

CAS No. 1469284-79-4

PF-06424439 methanesulfonate( —— )

Catalog No. M26369 CAS No. 1469284-79-4

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 50 Get Quote
10MG 87 Get Quote
25MG 177 Get Quote
50MG 295 Get Quote
100MG 484 Get Quote
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Biological Information

  • Product Name
    PF-06424439 methanesulfonate
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM).
  • Description
    PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor(IC50 of 14 nM). PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate.(In Vivo):PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male low-density lipoprotein receptor (Ldlr) knockout mice (Ldlr-/-)Dosage:60 mg/kg Administration:P.o.; daily; for 3 days Result:Reduced plasma TG and cholesterol levels and decreased nonsignificant in circulating lipids.Animal Model:Male Wistar-Han ratsDosage:1 mg/kg Administration:I.v.Result:Showed moderate clearance and a short half-life with t1/2=1.39 h.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PI4Kα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1469284-79-4
  • Formula Weight
    536.05
  • Molecular Formula
    C23H30ClN7O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (466.37 mM)
  • SMILES
    CS(O)(=O)=O.Clc1cnn(c1)C1(CC1)c1nc2ccc(nc2[nH]1)N1CCC[C@H](C1)C(=O)N1CCCC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anna Lindsey Banka, et al. Quinazolinone derivatives as antiviral agents.WO2012087938A1
molnova catalog
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